Alessio Signorini

CTO & Co-Founder at Evidation Health - Technologist, Product Leader, AI Researcher

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Santa Barbara, CA

I’ve been working on ML/AI since before it was cool — started with a PhD in Machine Learning & Epidemiology at the University of Iowa, worked in big search engines, launched a couple of startups, and more recently co-founded Evidation Health, a $1B digital health platform deeply infused with AI, where I lead a cross-functional org spanning product, engineering, infrastructure, security, data science, and TPM.

Search Dir. of Technology at Ask.com - relevance, classification, 7 patents
Ranking Dir. of Search at OneRiot - real-time social signals (→ Walmart)
Vision Co-founded IMRSV, CTO - computer vision for billboards (→ Kairos)
Health Co-founded Evidation, CTO - product & eng, wearables/EHR, health AI

I’m a very active technologist, tinkering daily with hardware and software on many projects, from IoT sensors to apps and LLM-powered tools. I advise and invest in early-stage startups, so let me know if you are building something cool.

I’m also a regular speaker at industry and academic conferences on topics ranging from AI and health tech to search and digital biomarkers. My research spans web search, disease surveillance, and digital biomarkers: 18 publications, 10 patents, and ~3,000 citations on Google Scholar. I am a TechStars and Rock Health alumn, and a Robert Wood Johnson Foundation award recipient. Feel free to reach out via email or connect on social media.


currently exploring

LayoverQuest — Turn your layovers into adventures. LayoverQuest helps travelers discover interesting stopover cities between any two destinations. Enter your origin, destination, and travel dates, and LayoverQuest scores candidate cities by interest, transit ease, and pricing — then surfaces the best options with flights, hotels, and an AI-generated city guide.
Tiny Markdown Render — Chrome extension that renders Markdown pages as beautifully formatted HTML. One click or fully automatic — no setup needed.
AppleNoted — Lightweight IMAP4rev1 encrypted server purpose-built for Apple Notes to edit and sync notes across macOS and iOS devices.
Candidates Manager — A clean, low-touch candidate tracking system powered by LLM. Provides a simple UI to review and manage candidates through the hiring pipeline. Forward your emails to its address to parse candidate information, resume, interviews, reviews, etc.
Securing OpenClaw via Proxy — An elegant solution for keeping OpenClaw from leaking credentials could be to put a proxy server between the bot and the outside world.

latest thoughts

The 10,000 Hour Reset - you need side projects — Remember that 10,000 hour rule from Outliers? The idea is simple: deliberate practice makes experts.
SaaS will suffer in 2026 — I think we are about to see a massive shift in how companies approach software, and SaaS vendors are going to feel the pain.
Teladoc and COVID Paved the Way for AI Doctors — Teladoc and the pandemic made completely normal to discuss your health concerns over a video meeting.