Alessio Signorini

CTO & Co-Founder at Evidation Health - Technologist, Product Leader, AI Researcher

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Santa Barbara, CA

I’ve been working on ML/AI since before it was cool — started with a PhD in Machine Learning & Epidemiology at the University of Iowa, worked in big search engines, launched a couple of startups, and more recently co-founded Evidation Health, a $1B digital health platform deeply infused with AI, where I lead a cross-functional org spanning product, engineering, infrastructure, security, data science, and TPM.

Search Dir. of Technology at Ask.com - relevance, classification, 7 patents
Ranking Dir. of Search at OneRiot - real-time social signals (→ Walmart)
Vision Co-founded IMRSV, CTO - computer vision for billboards (→ Kairos)
Health Co-founded Evidation, CTO - product & eng, wearables/EHR, health AI

I’m a very active technologist, tinkering daily with hardware and software on many projects, from IoT sensors to apps and LLM-powered tools. I advise and invest in early-stage startups, so let me know if you are building something cool.

I’m also a regular speaker at industry and academic conferences on topics ranging from AI and health tech to search and digital biomarkers. My research spans web search, disease surveillance, and digital biomarkers: 18 publications, 10 patents, and ~3,000 citations on Google Scholar. I am a TechStars and Rock Health alumn, and a Robert Wood Johnson Foundation award recipient. Feel free to reach out via email or connect on social media.


currently exploring

Tiny Markdown Render — Chrome extension that renders Markdown pages as beautifully formatted HTML. One click or fully automatic — no setup needed.
AppleNoted — Lightweight IMAP4rev1 encrypted server purpose-built for Apple Notes to edit and sync notes across macOS and iOS devices.
Candidates Manager — A clean, low-touch candidate tracking system powered by LLM. Provides a simple UI to review and manage candidates through the hiring pipeline. Forward your emails to its address to parse candidate information, resume, interviews, reviews, etc.
Securing OpenClaw via Proxy — An elegant solution for keeping OpenClaw from leaking credentials could be to put a proxy server between the bot and the outside world.
Startups Are Now Just MVPs for Tech Giants — Until recently, startups had a genuine speed advantage. Big corporations were tangled in bureaucracy, committees, and endless approval chains. A small team could ship innovative products in weeks while enterprise companies took months (or years). But Large Language Models changed everything.

latest thoughts

The 10,000 Hour Reset - you need side projects — Remember that 10,000 hour rule from Outliers? The idea is simple: deliberate practice makes experts.
SaaS will suffer in 2026 — I think we are about to see a massive shift in how companies approach software, and SaaS vendors are going to feel the pain.
Teladoc and COVID Paved the Way for AI Doctors — Teladoc and the pandemic made completely normal to discuss your health concerns over a video meeting.